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[1] [4] For patients with diabetes, additional monitoring for diabetic retinopathy is recommended, and those on insulin or sulfonylureas may require dose adjustments to prevent hypoglycaemia

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This classification system is visualised below Fun Fact: Prenatal diagnosis of cleft lip is possible through second-trimester ultrasound, with detection rates of 6090% (Smarius, 2017)

Prolyl-4-hydroxylase (PHD), which regulates the degradation of HIF, is highly Fe 2+ -dependent, causing HIF became iron metabolism pathologies treatment target